Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate

Table 3

The predictive value of S-creatinine, S-creatinine ratio, and CCR for delayed MTX elimination.

Parameters	AUC	value	Cut-off	Sensitivity	Specificity
S-creatinine 24 h	0.756 (0.672–0.840)	<0.001	>35.0	68.6%	70.1%
S-creatinine ratio 24 h	0.759 (0.668–0.850)	<0.001	>1.129	69.8%	80.0%
CCR_24 h	0.771 (0.688–0.854)	<0.001	<100.0	68.6%	74.1%
CCR ratio 24 h	0.728 (0.626–0.829)	<0.001	<0.824	67.4%	73.1%
S-creatinine 0 h	0.422 (0.324–0.519)	0.130
CCR_0 h	0.509 (0.409–0.608)	0.859

S-creatinine 24 h: serum creatinine level in 24 hours after MTX infusion; S-creatinine ratio 24 h: the ratio of serum creatinine level in 24 hours to creatinine level before MTX infusion; CCR_24 h: creatinine clearance rate in 24 hours after MTX infusion; CCR ratio 24 h: the ratio of CCR in 24 hours to CCR before MTX infusion; S-creatinine 0 h: serum creatinine level before MTX infusion; CCR_0 h: creatinine clearance rate before MTX infusion.