Clinical Study

Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate

Table 2

Possible parameters related to CCR decrease > 50%.

ParametersStandard Number ratioRelative risk95% CI value

Age ≥10 years<10 years41 versus 1320.810.09–7.300.852
Body surface area ≥1.0 m2<1.0 m251 versus 1221.770.24–12.960.573
MTX dosage (≥5 g/m2)<5 g/m260 versus 1130.980.24–4.100.979
S-creatinine 0 h ≥35 μmol/L<35 μmol/L58 versus 1150.310.07–1.440.134
_24 h ≥65 μmol/L<65 μmol/L74 versus 990.830.26–2.650.758
Delayed MTX eliminationNormal elimination53 versus 1208.072.57–25.32<0.001

S-creatinine 0 h: serum creatinine level before MTX infusion; _24 h: serum MTX concentration in 24 hours after MTX infusion.