Clinical Study

Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate

Table 1

Comparison of patients’ characteristics and serum MTX concentrations between patients with and without MTX elimination delay.

CharacteristicsWhole cohortNumber ratioNormal eliminationDelayed elimination value

Height (cm)110123 versus 50110.0108.50.629
Weight (kg)19.0123 versus 5020.019.00.493
Age (year)5.2123 versus 505.45.00.461
BSA (m2)0.85123 versus 500.750.750.615
S-creatinine 0 h (μmol/L)31.7110 versus 4132.830.90.083
S-creatinine 24 h (μmol/L)33.5120 versus 4831.642.5<0.001
S-creatinine 48 h (μmol/L)33.8122 versus 5030.547.4<0.001
S-creatinine ratio 24 h1.02110 versus 410.981.26<0.001
S-creatinine ratio 48 h1.01110 versus 410.951.39<0.001
CCR_0 h (mL/min)131.3111 versus 41130.1139.50.424
CCR_24 h (mL/min)111.3118 versus 48120.285.1<0.001
CCR_48 h (mL/min)102.7120 versus 49114.181.7<0.001
CCR_96 h (mL/min)97.712 versus 17113.886.40.008
_24 h (μmol/L)59.8123 versus 5054.570.5<0.001
_48 h (μmol/L)0.43123 versus 500.322.81<0.001
_96 h (μmol/L)0.04115 versus 490.020.25<0.001

S-creatinine 0 h: serum creatinine level before MTX infusion; S-creatinine 24 h: serum creatinine level in 24 hours after MTX infusion; S-creatinine 48 h: serum creatinine level in 48 hours after MTX infusion; S-creatinine ratio 24 h: the ratio of serum creatinine level in 24 hours to creatinine level before MTX infusion; S-creatinine ratio 48 h: the ratio of serum creatinine level in 48 hours to creatinine level before MTX infusion; CCR_0 h: creatinine clearance rate before MTX infusion; CCR_24 h: creatinine clearance rate in 24 hours after MTX infusion; CCR_48 h: creatinine clearance rate in 48 hours after MTX infusion; CCR_96 h: creatinine clearance rate in 96 hours after MTX infusion; _24 h: serum MTX concentration in 24 hours after MTX infusion; _48 h: serum MTX concentration in 48 hours after MTX infusion; _96 h: serum MTX concentration in 96 hours after MTX infusion.