Clinical Study

Methotrexate Associated Renal Impairment Is Related to Delayed Elimination of High-Dose Methotrexate

Figure 2

Comparison of renal function in normal and delayed MTX elimination. In normal MTX elimination patients, serum creatinine concentration (a) and creatinine ratio (b) were comparable while the CCR was slightly decreased 24 hours after MTX infusion (c). In delayed MTX elimination patients, serum creatinine concentration (d) and creatinine ratio (e) were gradually increased while CCR was decreased (f).
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(b)
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(f)