Gene Network Biological Validity Based on Gene-Gene Interaction Relevance

Figure 3

Two portions of real KEGG pathways with multiconnected nodes. (a) contains a fragment of the pathway where three genes are connected to the same compound. In the process of conversion to a gene network, new relationships between these genes are created. (b) shows a fragment of the pathway, illustrating how a compound is transferred by two genes. When the gene network is created, these two genes must be connected (as shown in the figure). Note genes HSD11B1, AKR1D1, and AKR1C4 (a) correspond to enzymes “1.1.1.146,” “1.2.1.3,” and “1.1.1.50,” respectively.