Ameliorative Potential of Tamarindus indica on High Fat Diet Induced Nonalcoholic Fatty Liver Disease in Rats

Table 2

Effect of ETS treatment for six weeks on terminal serum and hepatic parameters in HFD-fed rat model of NAFLD.

Parameters	I; ND control	II; NAFLD control	III; HFD + ETS at 45 mg/kg	IV; HFD + ETS at 90 mg/kg	V; HFD + ETS at 180 mg/kg
Liver index	2.43±0.04	2.89±0.12^a	2.25±0.08^b	2.34±0.07^b	2.29±0.06^b
MDA (nmol/g liver tissue)	17.91±1.70	32.26±4.03^a	13.90±1.04^b	14.06±1.17^b	14.53±1.36^b
Serum ALT (IU/L)	34.89±1.84	59.52±3.45^a	28.28±0.79^b	27.59±2.41^b	28.28±2.38^b
Serum free fatty acids (mEq/L)	0.86±0.06	2.04±0.25^a	0.72±0.06^b	0.69±0.09^b	0.74±0.11^b
Serum Insulin (µIU/mL)	18.65±1.37	29.68±3.21^a	23.34±2.08	28.77±2.38	26.20±2.67
Serum glucose (mmol/L)	3.94±0.31	4.98±0.33	4.31±0.16	3.92±0.29	3.78±0.15^b
HOMA	3.23±0.24	6.59±0.81^a	4.44±0.34	4.94±0.37	4.36±0.41

Values are expressed as Mean ± SEM; 𝑛=6; ^a𝑃≤0.05, NAFLD control versus ND control; ^b𝑃≤0.05, treated groups versus NAFLD control.
Liver index = (absolute liver weight/Body weight) * 100.
ETS: extract of Tamarindus indica seed coat; NAFLD: non-alcoholic fatty liver disease; ND: normal diet; HFD: high fat diet; MDA: malondialdehyde; ALT: alanine aminotransferase; HOMA: homeostatic model assessment.