Review Article
Optimization of Drug Delivery Systems for Intraperitoneal Therapy to Extend the Residence Time of the Chemotherapeutic Agent
Table 2
Advantages and disadvantages of the drug delivery systems investigated for IP therapy.
| Drug delivery system | Advantages | Disadvantages |
| Microspheres | Prolonged retention time | Limited tumor penetration Risk of peritoneal adhesions | Nanoparticles | Small size passive targeting Avoiding MDR Lower incidence of peritoneal adhesions | Rapid clearance out of the abdominal cavity | Liposomes | Similar to nanoparticles Active targeting by varying parameters | Similar to nanoparticles | Micelles | Prolonged retention time |
Increasing systemic toxicity | Injectable systems | Prolonged retention time Localized and sustained drug delivery Lower systemic toxicity Prevention against peritoneal adhesion | Viscosity issues | Implantable systems | Similar to injectable systems | Invasive Surgical expertise |
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