Decreased Expression of T-Cell Costimulatory Molecule CD28 on CD4 and CD8 T Cells of Mexican Patients with Pulmonary Tuberculosis

Table 3

Phenotype of peripheral blood T lymphocytes in 23 patients with active pulmonary tuberculosis and in 15 healthy controls.

Marker	Controls		TB Patients
	%	#	%	#
CD3	$66\pm 4$	1600 $\pm$ 137	56 $\pm$ 5*	1263 $\pm$ 161*
CD3/CD4	$39\pm 82$	948 $\pm$ 90	24 $\pm$ 2***	521 $\pm$ 47***
CD3/CD8	$22\pm 2$	520 $\pm$ 56	14 $\pm$ 2**	286 $\pm$ 36**
CD4/CD40L	$4\pm 1$	32 $\pm$ 10	11 $\pm$ 3	30 $\pm$ 7
CD8/CD40L	$4\pm 3$	21 $\pm$ 15	12 $\pm$ 6	56 $\pm$ 25
CD4/CD45RA	$17\pm 4$	212 $\pm$ 37	32 $\pm$ 5	206 $\pm$ 43
CD8/CD45RA	$61\pm 7$	330 $\pm$ 48	58 $\pm$ 7	265 $\pm$ 59
CD4/CD45RO	$52\pm 5$	486 $\pm$ 42	73 $\pm$ 4**	345 $\pm$ 39
CD8/CD45RO	$47\pm 5$	244 $\pm$ 39	45 $\pm$ 6	153 $\pm$ 29*
CD4/CD30	$1\pm 0.5$	8 $\pm$ 4	6 $\pm$ 2*	28 $\pm$ 12
CD8/CD30	$1\pm 0.3$	1 $\pm$ 1	5 $\pm$ 2*	15 $\pm$ 7
CD4/CD30L	$6\pm 1$	60 $\pm$ 12	23 $\pm$ 8	98 $\pm$ 23
CD8/CD30L	$3\pm 1$	17 $\pm$ 10	13 $\pm$ 3*	60 $\pm$ 21
CD4/CD28	$93\pm 2$	885 $\pm$ 82	48 $\pm$ 8**	268 $\pm$ 54***
CD8/CD28	$51\pm 3$	325 $\pm$ 26	24 $\pm$ 6**	63 $\pm$ 14***
CD4/CD95	$43\pm 8$	425 $\pm$ 86	54 $\pm$ 7	298 $\pm$ 49
CD8/CD95	49 $\pm$ 7	280 $\pm$ 51	40 $\pm$ 8	155 $\pm$ 38
CD4/CD27	42 $\pm$ 10	401 $\pm$ 107	50 $\pm$ 9	275 $\pm$ 56
CD8/CD27	32 $\pm$ 8	154 $\pm$ 40	29 $\pm$ 7	81 $\pm$ 20

Media absolute cell counts and percentage $\pm$ SD of flow cytometry, results. Statistically significant differences between controls and tuberculosis patients were determined by a Mann-Whitney nonparametric test. *$P<.05$, **$P<.01$, ***$P<.001$.