The Soluble Plasminogen Activator Receptor as a Biomarker on Monitoring the Therapy Progress of Pulmonary TB-AFB(+) Patients

Table 2

Comparison between medical records used to monitor TB theraphy progress in Indonesia, that is, patients complaints, BMI (kg/m²), width of lesion, sputum AFB, erythrocyte sedimentation rate (mm/hour), monocyte count (cell/mm²), and soluble urokinase plasminogen activator receptor during the 6-month therapy.

	During anti-TB-drugs treatment
No.	Medical records and level of suPAR	Before Treatment	2 months	4 months	6 months	$P$-value $<$.05
1	Patients’ Complaints
	Chronic cough $>$3 weeks	20 (100%)	17 (85%)		5 (25%)
	Decrease of appetite	15 (75%)	0 (0%)		0 (0%)
	Low grade fever	10 (50%)	0 (0%)		0 (0%)
	Shortness of breath	9 (45%)	5 (25%)		3 (15%)
	Hemoptoe	9 (45%)	0 (0 %)		0(0 %)
	Chest pain	2 (10 %)	1 (5 %)		1 (5 %)
2	BMI	18.28 $\pm$ 2.12	19.18 $\pm$ 2.31		20.36 $\pm$ 2.35	.0001
3	Width of lesion classification		Thoracic Imaging $n=20$		Thoracic Imaging $n=20$
	Minimal Lesion; Mod Advance Lesion; Far Advance Lesion	1 (5%); 7 (35%); 12 (60%)	$\left\{\begin{array}{c}\text{Worsen}:\mathrm{\hspace{0.17em}\hspace{0.17em}}0\mathrm{\hspace{0.17em}\hspace{0.17em}}(0\text{\%})\mathrm{\hspace{0.17em}\hspace{0.17em}}\\ \text{Unchange}:\mathrm{\hspace{0.17em}\hspace{0.17em}}3\mathrm{\hspace{0.17em}\hspace{0.17em}}(15\text{\%})\\ \text{Getting}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{better}:\mathrm{\hspace{0.17em}\hspace{0.17em}}17\mathrm{\hspace{0.17em}\hspace{0.17em}}(85\text{\%})\mathrm{\hspace{0.17em}\hspace{0.17em}}\end{array}\right\}$		$\left\{\begin{array}{c}\text{Worsen}:\mathrm{\hspace{0.17em}\hspace{0.17em}}1\mathrm{\hspace{0.17em}\hspace{0.17em}}(5\text{\%})\\ \text{Unchange}:\mathrm{\hspace{0.17em}\hspace{0.17em}}0\mathrm{\hspace{0.17em}\hspace{0.17em}}(0\text{\%})\mathrm{\hspace{0.17em}\hspace{0.17em}}\\ \text{Getting}\mathrm{\hspace{0.17em}\hspace{0.17em}}\text{better}:\mathrm{\hspace{0.17em}\hspace{0.17em}}19\mathrm{\hspace{0.17em}\hspace{0.17em}}(95\text{\%})\end{array}\right\}$
4	Sputum AFB(+)	20 (100%)	5 (25%)		0(0%)
5	ESR	84.15 $\pm$ 32.47	44.10 $\pm$ 29.97		19.30 $\pm$ 13.29	.0001
6	Monocytes Count	847.00 $\pm$ 244.52	662.00 $\pm$ 241.72		496.50 $\pm$ 129.67	0.0001
7	Level of suPAR	12.775 $\pm$ 3.940	8.019 $\pm$ 1.458	5.771 $\pm$ 0.796	5.009 $\pm$ 0.842	.0001