A Crossover Comparison of the Sensitivity and the Specificity between BIS and AEP in Predicting Unconsciousness in General Anesthesia

Table 11

Propofol/sevoflurane concentration, BIS/AEP values, and prediction probabilities at unconsciousness (mean (95% CI).

	EC5		EC50		EC95		Sensitivity (%)		Specificity (%)		Prediction probability
	Propofol	Sevoflurane	Propofol	Sevoflurane	Propofol	Sevoflurane	Propofol	Sevoflurane	Propofol	Sevoflurane	Propofol	Sevoflurane
Blood concentration (g/ml)/Fi (%)	1.9	2.3	3.2 (3–3.4)	3.3 (3.2–3.4)	4.5	4.3	85	79	81	66	0.83	0.72
Effect-site concentration (g/ml)/ET (%)	1.3	1.1	2.3 (2.2–2.4)	2.2 (2.1–2.3)	3.3	3.3	83	79	73	75	0.78	0.77
BIS	77	93	57 (55–59)	58 (54–61)	37	23	79	77	72	77	0.76	0.77
AEP	61	85	32 (30–35)	48 (45–52)	4	12	71	68	79	82	0.75	0.75