TY - JOUR
A2 - Lai, Yuan-Yang
AU - Calcaianu, George
AU - Bresson, Didier
AU - Calcaianu, Mihaela
AU - Morisset, Beatrice
AU - El-Nazer, Tarek
AU - Deodati, Clara
AU - Virot, Edouard
AU - Holtea, Daniela
AU - Iamandi, Carmen
AU - Debieuvre, Didier
PY - 2019
DA - 2019/01/21
TI - The Importance of Apneic Events in Obstructive Sleep Apnea Associated with Acute Coronary Syndrome
SP - 6039147
VL - 2019
AB - Background. Obstructive sleep apnea (OSA) is a potential cardiovascular risk factor. However, there is currently no prominent screening strategy for its diagnosis in patients with acute coronary syndrome (ACS). The aim of this study was to establish the impact of apneic events in case of OSA associated with ACS. Methods. Between January 1st and June 30th, fifty-three subjects with ACS (first acute myocardial infarction) were prospectively evaluated for OSA. Each patient was evaluated by polysomnography (PSG) two months after the ACS. Results. Mean age of 59±9,6 years, 81,1% males, BMI at 28,5±4,2 kg/m2, neck circumference of 42,5±12,6 cm, and waist circumference os 102,5±16,5 cm. The majority of patients (73,6%) had moderate to severe OSA (apnea-hypopnea index (AHI) ≥ 15/h and arousal index ≥ 10/h). We defined the apneic coefficient (AC) as the ratio between apnea index (AI) and AHI. We chose as cut-off the median value of apnea coefficient in our population which was at 37%. The patients with a higher AC (AC ≥ 37% versus AC < 37%) had higher levels of Troponin-I (63,4±63,2 versus 29,7±36,1 ng/mL, p=0,016), higher levels of NT-proBNP (1879,8±2141,8 versus 480±621,3 pg/mL, p=0,001), higher SYNTAX score (15,8±11,5 versus 10,2±5,9, p=0,049), and lower left ventricle ejection fraction (LVEF 53,3±11,4 versus 59,4±6,4%, p=0,023) and were more likely to have a STEMI (21 patients (77,7%) vesus 14 patients (53,8%), p=0,031). Conclusion. An apneic coefficient (AI/AHI) ≥ 37% is correlated with more severe cardiac impairment, as well as higher hypoxemia and arousal index.
SN - 2090-3545
UR - https://doi.org/10.1155/2019/6039147
DO - 10.1155/2019/6039147
JF - Sleep Disorders
PB - Hindawi
KW -
ER -