Systems Biology Genetic Approach Identifies Serotonin Pathway as a Possible Target for Obstructive Sleep Apnea: Results from a Literature Search Review

Box 1

Top 23 candidate genes identified by enrichment analysis. The box shows the 23 unique genes (in alphabetical order) identified from Enrichr analysis. The majority of the pathway genes are involved in serotonin based regulatory pathways.

Selected genes associated with OSA

APOA5: apolipoprotein A-V

ADRA1B: adrenoceptor alpha 1B

ADRA2A: adrenoceptor alpha 2A

ADRB1: adrenoceptor beta 1

ADRB2: adrenoceptor beta 2, surface

ECE1: endothelin converting enzyme 1

EDNRA: endothelin receptor type A

EDN1: endothelin 1

HIF1A: hypoxia inducible factor 1, alpha subunit

HTR1B: 5-hydroxytryptamine (serotonin) receptor 1B

HTR2A: 5-hydroxytryptamine (serotonin) receptor 2A

HTR2C: 5-hydroxytryptamine (serotonin) receptor 2C

HTR3A: 5-hydroxytryptamine (serotonin) receptor 3A

HTR3B: 5-hydroxytryptamine (serotonin) receptor 3B

HTR3C: 5-hydroxytryptamine (serotonin) receptor 3C

HTR3D: 5-hydroxytryptamine (serotonin) receptor 3D

HTR3E: 5-hydroxytryptamine (serotonin) receptor 3E

IRS1: insulin receptor substrate 1

LEP: leptin

LEPR: leptin receptor

LIPC: lipase, hepatic

LPL: lipoprotein lipase

NOS3: nitric oxide synthase 3 (endothelial cell)

SLC6A4: solute carrier family 6 (neurotransmitter transporter), member 4