Systems Biology Genetic Approach Identifies Serotonin Pathway as a Possible Target for Obstructive Sleep Apnea: Results from a Literature Search Review

Figure 1

(a) Clustergram showing the top 10 highly significant gene ontology molecular functions associated with OSA. The selected genes () were imported into Enrichr web tool using default setting. The top GO molecular activity was ranked based on enrichment scores (combined Fisher’s exact test values and the -scores). The top 10 associated molecular functions are () serotonin receptor activity, () G-protein coupled amine receptor, () catecholamine binding, () cytokine receptor binding, () cytokine activity, () growth factor activity, () adrenergic receptor activity, () G-protein coupled receptor, () G-protein coupled peptide receptor, () and peptide hormone binding. (b) Clustergram showing the top 10 highly significant KEEG pathways associated with OSA. The selected genes () were imported into Enrichr web tool using default setting. The top KEEG pathways were ranked based on enrichment scores (combined Fisher’s exact test values and the -scores). The top 10 highly significant OSA disease pathways include () serotonin receptor interaction, () pathways in cancer, () AGE-RAGE signaling in diabetes, () infectious diseases, () serotonergic synapse, () inflammatory bowel disease, () HIF-1 signaling pathway, () PI3-AKT signaling pathway, () regulation lipolysis in adipocytes, and () rheumatoid arthritis.

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