Review Article

Medicinal Plants as a Drug Alternative Source for the Antigout Therapy in Morocco

Table 2

List of plants used in Moroccan alternative medicine as antigout.

Scientific nameFamilyTraditional used partTraditional method of useExperimentalused partExtraction methodsExperimental studyResultsToxicityRef.

Ailanthus altissimaSimaroubaceaeFlowersInfusionFlowersDecoction (distilled water)In vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[2123]
Artemisia herba-albaAsteraceaeFlowersInfusionFlowersDecoction (distilled water)In vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 24, 25]
Capparis spinosa L.CaparidaceaeFruitMixed the dried fruit with honeyRoot and aerial partMaceration (distilled water, methanol, hexane, chloroform, and ethyl acetate)In vitroInhibition of xanthine oxidase (crude extract of root, IC50, 0.32, 0.36, and 4.32 mg/mL) (crude extract of aerial part, IC50, 0.023, 0.09, and 1.35 mg/mL)No[2628]
Caryophyllus aromaticus L.MyrtaceaeFlowersInfusionFlowersDecoction (distilled water)In vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 24, 29]
Citrullus colocynthis L.CucurbitaceaePulpDecoction (water and honey) and macerationLeavesSoxhlet extraction (hexane, chloroform, and methanol)In vitroInhibition of xanthine oxidase
IC50 = 0.58
IC50 = 1.8
IC50 = 5.96
Toxic
LD50 = 2500 mg/kg
[26, 30, 31]
Colchicum autumnale L.LiliaceaeSeeds and capsuleAntigout actionToxic[10, 31]
Ginkgo biloba L.GinkgoaceaeLeavesInfusionLeavesDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 3234]
Hyssopus officinalis L.LamiaceaeFlowersInfusionFlowersDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 3537]
Lavandula angustifoliaLamiaceaeFlowersInfusionFlowersDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 26, 37]
Melissa officinalis L.LamiaceaeLeavesInfusionLeavesDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseHepatotoxic[21, 26, 38]
Mentha spicata L.LamiaceaeLeavesInfusionLeavesDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 39, 40]
Rosmarinus officinalis L.LamiaceaeLeavesInfusionLeavesDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 24, 37]
Smilax officinalis
Smilax medica
Smilax syphilitica
Smilax aristolochiifolia Mill
Smilax febrifuga Kunth.
Smilax regelii Killip and C.V. Morton Smilax aspera L.
SimilaceaeRootCooking the herb with the meat.RhizomeMacerationIn vitroInhibition of xanthine oxidase
IC50 = 33% (methanol extract)
IC50 = 96% (water extract)
No[26, 41, 42]
Solidago virgaurea L.AsteraceaeLeavesInfusionLeavesDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 43, 44]
Thymus vulgaris LLamiaceaeLeavesInfusionLeavesDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 45, 46]
Urtica dioica L.UrticaceaeLeavesInfusionLeavesDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 24, 47]
Zea mays L.PoaceaeStigmaInfusionStigmaDecoctionIn vitro (0.1, 0.5, 1.0, and 2.0 mg/mL)Inhibition of xanthine oxidaseNo[21, 45, 48]