Adaptive Evolution Coupled with Retrotransposon Exaptation Allowed for the Generation of a Human-Protein-Specific Coding Gene That Promotes Cancer Cell Proliferation and Metastasis in Both Haematological Malignancies and Solid Tumours: The Extraordinary Case of MYEOV Gene

Figure 3

Presence of L2 family-repeat-fossils in MYEOV evolutionary antecedents. Upper panel: illustrated on top is MYEOV locus, as described in Figure 1. Shown is the location of the sense orientation L2 family-repeat followed by RepeatMasker’s annotation in the context of the subfamily name appearing in consensus annotation evidence (dark blue font), the size (black font), and the Smith-Waterman score (red font) of the match. Lower panel: depicted is the presence of L2 family-repeat-relics (pentagons) in MYEOV syntenic region in six mammals, ranging from armadillo to western gorilla. Blue, discontinuous, vertical lines have been used to better visualize the overlap with the human repeat as well as, wherever occurring, the overlap with nonmasked human sequences. Shown in the left flank is the NCBI accession of WGS sequence contigs including the syntenic DNA sequence in each species, followed by the RepeatMasker’s annotation of the degenerated repeat element included in the syntenic region. Length of white rhinoceros and armadillo repeats in the figure is not in accordance with the nucleotide content due to the presence of inserts in the syntenic region.