Tissue Factor Structure and Function

Figure 3

The extracellular domain of TF on a modeled lipid membrane. The figure shows in red the three sites of glycosylation (Asn¹¹, Asn¹²⁴ and Asn¹³⁷). Highlighted in green are residues important for TF interaction with factor VIIa (Thr¹⁷, Lys²⁰, Ile²², Glu²⁴, Gln³⁷, Asp⁴⁴, Lys⁴⁶, Lys⁴⁸, Asp⁵⁸, Thr⁶⁰, Phe⁷⁶, Tyr⁷⁸, Gln¹¹⁰, Leu¹³³, Arg¹³⁵, Phe¹⁴⁰, and Val²⁰⁷). Highlighted in magenta are residues important for the interaction with factor X (Thr¹⁵⁴-Glu¹⁷⁴ and Tyr¹⁸⁵). Highlighted in aqua are the residues important for TF interaction with the membrane (Gln¹¹⁸, Val¹¹⁹, Thr¹²¹, Lys¹⁵⁹, Asp¹⁸⁰, Lys¹⁸¹, and Glu¹⁸³). Also shown in yellow are the two disulfide bridges of TF at positions Cys⁴⁹-Cys⁵⁷ and Cys¹⁸⁶- Cys²⁰⁹. (This figure was originally published in Biochim Biophys Acta) [10].