Skin stem/progenitor cells hold great promise for regenerative medicine and cosmetic skin care. The success of stem cell-based approaches lies in the ability to understand and regulate skin stem cell populations in skin anatomy and physiology for skin repair and regeneration. Skin regeneration, either after injury or usually replacing dead skin in the ageing process, is critically regulated by cellular and molecular factors in the microenvironment of skin tissue during the lifespan of an organism. Cellular and molecular factors play an important role in activating stem cells to divide and transform into skin tissue-making cells. Under injury conditions or ageing process of skin, endogenous stem cell populations govern skin regeneration. Furthermore, skin stem cells approaches are routinely practiced for antiageing skincare. Skin stem cells are multipotent endogenous adult stem cells present in skin tissue, which have the capacity for self-renew and differentiate into different cell lineages of the skin under the influence of microenvironmental niches. In general, skin stem cells are silent but active during skin renewal and in skin repair after injury or ageing process. Current research reports bring new details to the understanding of how skin stem cells maintain and lose their status as local stem cells for skin regeneration.

The phenotype of skin approaches depends on environment and lifestyle, which involve cellular and molecular changes for skin appearance. In this special issue, we focus on recent cellular and molecular factors for regulation of stem cells for skin regeneration and how this may contribute to ageing, especially for skin repair and its appearance. To highlight the tremendous accumulating preclinical and clinical evidence about the endogenous stem cell and exogenous stem cell approaches for skin regeneration as well as cosmetic skin care, this special issue aims to publish new and current evidence for skin ageing and skin regeneration especially focusing on skin stem cells based treatment for several skin diseases including diabetic wound, skin burn, and cosmetic skin care.

The goal of this special issue is to gather the innovative approaches to direct future scientific efforts toward the clinical application of stem/progenitor cells in the treatment of skin diseases. To highlight the tremendous advances taking place in the field, this special issue aims to discuss new strategies for circumventing the hurdles in skin regeneration by exploiting exogenous and endogenous stem cells. Herein, the special issue aims to make more comprehensive understanding and identification of the impact of stem/progenitor cells in the treatment of skin disorders as well as skin disease modelling. Therefore, we welcome original research articles as well as review articles.

Potential topics include but are not limited to the following:

• Endogenous stem cells system in skin anatomy and physiology in healthy skin and diseases conditions
• Identification and characterization of novel stem/progenitor cell populations in skin tissues
• Skin stem cells and their microenvironmental niches for skin repair and regeneration
• Molecular and epigenetic mechanisms governing skin stem cell self-renewal and differentiation towards repair and regeneration
• Signaling and cellular factors for skin regeneration
• Combining approaches for nanostructured materials and skin stem cells for skin repair and regeneration
• Dynamic interactions between microRNAs and skin stem cells /progenitor cells for balance self-renewal and early lineage commitment for skin repair and regeneration
• Recent stem cell-based regenerative approaches for diabetic wounds and other skin injuries
• Skin regeneration scaffolds for skin tissue engineering
• Transdermal and topical drug delivery using stem cells: from theory to clinical practice/ cosmetic practice
• Efficient gene editing in skin stem cells for treatment of skin diseases
• Impact of dietary and lifestyle factors on skin regeneration and its appearance
• Translational research and protocols of stem cells therapies for skin regeneration
• Induced pluripotent stem cells based micro-physiological skin models for skin diseases modelling and their high-throughput screening