Exosomes from Bone Marrow Microenvironment-Derived Mesenchymal Stem Cells Affect CML Cells Growth and Promote Drug Resistance to Tyrosine Kinase Inhibitors

Figure 4

The transfer of miR-15a via hBMMSC-Exo. (a) The relative expression of miR-15a in hBMMSC and hBMMSC-Exo. (b) K562 cells were incubated with various concentrations of hBMMSC-Exo (0, 50, 100, 150, and 200 μg/mL) for 48 h, and the miR-15a levels were evaluated. (c) K562 cells were transfected with miR-15a inhibitor (100 nM) and incubated with hBMMSC-Exo (150 μg/mL) for 48 h. Then, the proliferation of K562 cells was examined. The data were expressed as the of the three independent experiments. Student’s -test.

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