Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects

Figure 4

Qualitative and qualitative histomorphometry. Representative images depicting Masson trichrome stained coronal plane of the alveolar bone regions from rats treated with Gelfoam® alone and Gelfoam®+hMSCs for 1 (a), 4 (b), and 12 (c) weeks are shown. The intact and the defect sites are labelled in full tissue images, and the defect region has been expanded below respective images. Bone regeneration ratio values (d) from images demonstrate the level of bone formation within the defect site between week 1 and weeks 4 and 12, respectively, for both Gelfoam® alone and Gelfoam®+hMSCs. There is a statistically significant bone regeneration in 4 weeks in the presence of hMSCs.

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