| Indicators | Timepoint | Study number | test value | Model selected | WMD (95% CI) | |
| Scr | 1 day | 13 | <0.00001 | Random | -0.56 (-0.78, -0.34) | <0.00001 | 2 days | 5 | 0.0002 | Random | -0.58 (-0.89, -0.28) | 0.0002 | 3 days | 15 | <0.00001 | Random | -0.65 (-0.84, -0.45) | <0.00001 | 5 days | 4 | <0.00001 | Random | -0.35 (-0.54, -0.16) | 0.0003 | 7 days | 7 | <0.00001 | Random | -0.14 (-0.28, -0.00) | 0.05 | >7 days | 5 | <0.00001 | Random | -0.22 (-0.36, -0.08) | 0.002 | BUN | 1 day | 7 | 0.04 | Random | -11.72 (-18.80, -4.64) | 0.001 | 2 days | 3 | 0.38 | Fixed | -33.60 (-40.15, -27.05) | <0.00001 | 3 days | 10 | <0.00001 | Random | -21.14 (-26.15, -16.14) | <0.00001 | 5 days | 2 | 0.20 | Fixed | -8.88 (-11.06, -6.69) | <0.00001 | 7 days | 2 | 0.79 | Fixed | -0.72 (-13.49, -12.05) | 0.91 | >7 days | 2 | <0.00001 | Random | -90.84 (-257.31, 75.62) | 0.28 | Proteinuria | 3 days | 3 | <0.00001 | Random | -0.45 (-0.61, -0.30) | <0.00001 | >7 days | 2 | 0.21 | Fixed | -108.55 (-110.31, -106.78) | <0.00001 | MDA | — | 4 | 0.0001 | Random | -5.51 (-10.57, -0.45) | 0.03 | GSH | — | 2 | 0.0002 | Random | -31.40 (-21.52, 84.31) | 0.24 | CAT | — | 2 | <0.00001 | Random | 10.82 (-4.30, 25.95) | 0.16 | SOD | — | 2 | 0.41 | Fixed | 18.95 (16.86, 21.04) | <0.00001 | NOX1 | — | 3 | <0.00001 | Random | -0.32 (-0.54, -0.10) | 0.004 | NOX2 | — | 4 | <0.00001 | Random | -0.19 (-0.28, -0.10) | <0.0001 | PARP1 | — | 4 | <0.00001 | Random | -0.22 (-0.34, -0.09) | 0.0006 | Caspase 3 (mRNA) | — | 2 | <0.00001 | Random | -3.40 (-6.13, -0.68) | 0.01 | Caspase 3 (protein) | — | 3 | <0.00001 | Random | -0.15 (-0.21, -0.08) | <0.00001 | Bax | — | 3 | <0.00001 | Random | -0.25 (-4.42, -0.08) | 0.004 | TNF-α | — | 5 | <0.00001 | Random | -0.15 (-0.31, -0.02) | 0.08 | NFκB | — | 3 | <0.00001 | Random | -0.36 (-0.66, -0.05) | 0.02 | IL1β (mRNA) | — | 2 | 0.007 | Random | -3.26 (-4.37, -2.15) | <0.00001 | IL1β (protein) | — | 3 | <0.00001 | Random | -0.37 (-0.57, -0.17) | 0.0003 | IL4 | — | 2 | <0.00001 | Random | 0.13 (0.02, 0.23) | 0.02 | IL6 (mRNA) | — | 2 | <0.00001 | Random | -2.34 (-4.75, 0.07) | 0.06 | IL10 (mRNA) | — | 2 | 0.13 | Fixed | 0.27 (0.24, 0.29) | <0.00001 | IL10 (protein) | — | 3 | <0.00001 | Random | 0.45 (0.04, 0.86) | 0.03 | TGF-β | — | 2 | <0.00001 | Random | -18.89 (-55.79, 18.02) | 0.32 | Renal damage score | 1 day | 4 | <0.00001 | Random | -14.50 (-19.10, -9.90) | <0.00001 | 3 days | 4 | <0.00001 | Random | -1.19 (-1.72, -0.66) | <0.0001 |
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