Activator Protein-1 Transcriptional Activity Drives Soluble Micrograft-Mediated Cell Migration and Promotes the Matrix Remodeling Machinery

Figure 7

Schematic representation of the ERK-mediated mechanisms of MG treatment. Upon MG treatment, healing-associated growth factors present in the soluble fraction of the micrograft activate the MAPK signaling pathway, resulting in the phosphorylation of ERK. c-Jun and Fra-1 undergo dimerization to form the transcription factor AP-1. Once phosphorylated by ERK, AP-1 stabilizes in the nucleus to bind promoter regions of Fosl1, establishing a feedback loop. Additionally, AP-1 also binds the promoter regions of wound healing-associated genes, such as those involved in the regulation of cell migration.