Expanded CD133⁺ Cells from Human Umbilical Cord Blood Improved Heart Function in Rats after Severe Myocardial Infarction

Figure 1

Expanded CD133⁺ cells acquired an endothelial-like immunophenotype and greatly diminished the mortality of rats with AMI. (a) Percentage of positive cells with progenitor and endothelial cell markers. Representative immunoprofile of a sample of CD133⁺ cells isolated from human umbilical cord blood before (purified CD133⁺ cells) and after expansion (expanded CD133⁺ cells). (b) Percentage of mortality of the three groups: control (injected with isotonic saline solution, sodium chloride 0.9%), purified (transplanted with purified CD133⁺ cells), and expanded (transplanted with expanded CD133⁺ cells). The differences between groups are expressed as the delta value (Δ) above the bars.

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