In Vivo Immunogenic Response to Allogeneic Mesenchymal Stem Cells and the Role of Preactivated Mesenchymal Stem Cells Cotransplanted with Allogeneic Islets

Figure 5

Cotransplantation of preactivated MSCs prolongs islet graft survival in mice. Blood glucose concentration was measured daily in the mice transplanted with 300 islets alone (a) () or 300 islets + 2 × 10⁵ preactivated MSCs (b) (). Graft rejection was confirmed after two consecutive blood glucose measurements above 280 mg/dL. The percentage of normoglycemic mice overtime was compared between the groups (c). Average rejection time of the islet alone group was 13.12 ± 2.80 days compared to 19.83 ± 3.43 in the islet + preactivated MSCs. The mice transplanted with syngeneic islet () remained normoglycemic for at least 30 days after transplantation. , log-rank test.

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(b)

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