(Mesenchymal) Stem Cell-Based Therapy in Cisplatin-Induced Acute Kidney Injury Animal Model: Risk of Immunogenicity and Tumorigenicity

Table 3

The acute lethal single dose of cisplatin varies among various strains of mice and rats.

Strain (origin), sex, age	Cisplatin dose	Mortality	Time	Ref.
Wistar rats female	10.8 mg/kg (9.1–12.8 mg/kg)	50%	D10	[43]
Fischer 344 rats female, 8 wks	11 mg/kg	50%	D6	[44, 45]
BALB/c (Harlan); female	14.5 mg/kg	100%	D7	[46, 47]
C57BL/6 (Japan); Male, 11–15 wks	15 mg/kg	100%	D10	[48]
Swiss Webster male	16.0 ± 0.8; 19.5. ± 0.8	50%; 100%	D10	[49]
C57BL/6 x DBA/2 (F1) male	10 mg/kg; 14 mg/kg	0%; 90%	D8	[49]
DBA2 mice female	10.7 mg/kg; 16 mg/kg	50%; 90%	D10; D30	[43]
129SV; Male, 8–12 wks	14 mg/kg	70%	D7	[50]
CBA (UK); Male, 6 wks	10 mg/kg; 15 mg/kg	0%; 67%	D15	[51]
CBA mice; Female, 4–8 wks	16 mg/kg	40%	D8	[52]
CBA mice; Female, 24 months	16 mg/kg	100%	D7	[53]
NMRI mice female	17.0 mg/kg (14.9–19.7 mg/kg)	50%	D10	[43]

D: days after cisplatin injection.