Reversal of Experimental Liver Damage after Transplantation of Stem-Derived Cells Detected by FTIR Spectroscopy

Figure 6

Principal component analysis (PCA) score plots (a) and loading plots (b). Spectra were processed to the 2nd derivative over the spectral range between 1770–1500 cm⁻¹ and 1190–970 cm⁻¹ prior to PCA. Average spectra for DNM-injured liver (), DNM-injured liver + rBM-MSCs (), DNM-injured liver + rBM-MSC-DSCs (), and normal liver () from rats for each experiment. Each point on the score plot represents a mean spectrum, with each calculated from 12 spectra. Principal component 1 (PC1) is a vector in the direction of the greatest variance in the data set (explaining 69% of total variance), and principal component 2 (PC2) is in the direction of the next major source of variance (explaining 19% of total variance) that is independent to variance explained by PC1. The loadings plots show which spectral bands were most responsible for the clustering observed in the scores plot.

(a)

(b)