Astrocytes at the Hub of the Stress Response: Potential Modulation of Neurogenesis by miRNAs in Astrocyte-Derived Exosomes

Table 4

miRNA associated with neurogenesis modified after different stimulus.

miRNA	Expression level	Cellular process	Molecular target	Reference
miR-181a	Upregulated by morphine	Promote astrocyte-preferential differentiation of NSPCs	Prox1/Notch2	[159]
miR-23b	Upregulated by morphine	Adult neurogenesis	Morphine receptor expression (MOR1)	[160]
miR-190	Downregulated by fentanyl	Adult neurogenesis	NeuroD	[161]
miR-143	Upregulation by IGF-1	Promotes proliferation, neural differentiation, and cell survival	PDGFRA, PRKCE, MAPK7, DSSP, DMP-1, KRAS, and BCL-2	[162]
miR-181c	Upregulation by IGF1/LIF	Enhanced self-renewal of NSPCs	PTPN11, PTPN22, PTEN, Dusp6, PBX3, ZEB2, and IRF8	[162]