A Controlled Release Codelivery System of MSCs Encapsulated in Dextran/Gelatin Hydrogel with TGF-β3-Loaded Nanoparticles for Nucleus Pulposus Regeneration

Figure 5

CCK-8 result of the MSCs cultured in the dextran/gelatin hydrogel encapsulated with no supplement (control), 1000 μg/mL blank PLGANPs (PLGANPs), 1000 μg/mL TGF-β3-loaded PLGANPs (TGF-β3-PLGANPs), and the hydrogels with no supplements cultured in the medium containing 10 ng/mL TGF-β3 (TGF-β3) for 7, 14, and 28 days. The hydrogels with no seeded cell were chosen as the negative control. The data were expressed as the mean ± SD (). The samples indicated with () had a significant difference between the two groups (). The samples indicated with (A) had a significant difference compared to the same group on day 7 () and (B) had a significant difference compared to the same group on day 14 ().