Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment

Figure 6

hMSC origin and impact on Pseudomonas aeruginosa growth. The availability of different hMSC sources provides the opportunity to explore whether the antimicrobial effectiveness of the hMSC supernatant was dependent on the tissue origin of the hMSC. Like the bone marrow derived hMSCs, hMSCs derived from adipose tissue significantly decreased Pseudomonas aeruginosa CFUs () and enhanced geneticin (100 μg/mL) effectiveness (, ). PA = Pseudomonas aeruginosa growth without treatment. Geneticin = treatment with the antibiotic geneticin, +hMSCs = treatment with hMSC derived supernatant, and Both = treatment with both hMSC supernatants and geneticin. hMSC supernatants enhance antibiotic effectiveness against Pseudomonas aeruginosa.