Antimicrobial Properties of Mesenchymal Stem Cells: Therapeutic Potential for Cystic Fibrosis Infection, and Treatment
hMSCs in the PA (a) and SA (b) infection model: Cftrtm1Kth (CF) and wild type (WT) controls were infected with 105 CFUs of either Pseudomonas aeruginosa or Staphylococcus aureus impregnated into agarose beads to generate chronic gram negative or gram positive chronic infection models in CF. hMSCs were administered on day 1, 24 hours after infection. Mice were followed up to 10 days and were then euthanized for bacteria burden (BAL CFUs+ whole lung homogenate CFUs, experiments with 10 animals in each group). hMSCs decreased bacteria burden () in response to both pathogens.
(a) BAL Pseudomonas aeruginosa CFUs
(b) BAL Staphylococcus aureus CFUs
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