Novel Action of FSH on Stem Cells in Adult Mammalian Ovary Induces Postnatal Oogenesis and Primordial Follicle Assembly

Figure 2

Novel action of FSH on adult mammalian ovary. (a) Effect of pregnant mare serum gonadotropin (PMSG) on intact and chemoablated mice ovaries. (A)-(B) PMSG treatment to intact ovaries results in increased cohorts of primordial follicles below the OSE compared to untreated control [15]. (C)-(D) Chemoablated mouse OSE also responds to PMSG treatment. Note overall thickening of OSE after PMSG treatment compared to untreated control. Chemoablated ovaries are otherwise devoid of follicles [16]. (b) Effect of FSH on human ovary surface epithelium cortical tissue in vitro [17]. H&E stained paraffin section on D0 at the start of culture exhibits a prominent OSE and the cortical tissue is almost degenerated by D3 in culture whereas FSH exerts a survival effect on the cortical tissue and note the hypertrophied nature of the OSE. Please refer to the cited references for further details.

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