SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes

Figure 3

MSCs migrated to the damaged liver and had the proliferative activity. (a) IF analysis of Ki-67 expression (red) to visualize primary hepatocyte cells indicated that some of the donor GFP⁺ MSCs (green) are overlapped. Nuclear DAPI (blue) staining was used as a counterstain. The images were then merged. Bar: 75 μm. Arrow was directed to the double positive cells. All the experiments were repeated three times, at least 3 samples were included in each group. (b) Quantitative data of the GFP and Ki67 positive cells in IHC of different days after injuring (^***).

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