TY - JOUR A2 - Motohashi, Norio AU - Hao, Ning-Bo AU - Li, Chang-Zhu AU - Lü, Mu-Han AU - Tang, Bo AU - Wang, Su-Min AU - Wu, Yu-Yun AU - Liang, Guang-Ping AU - Yang, Shi-Ming PY - 2015 DA - 2015/08/02 TI - SDF-1/CXCR4 Axis Promotes MSCs to Repair Liver Injury Partially through Trans-Differentiation and Fusion with Hepatocytes SP - 960387 VL - 2015 AB - MSCs have become a popular target for developing end-stage liver therapies. In this study, two models of bone marrow chimeric mice were used to construct the liver failure models. Then it was found that MSCs can transdifferentiate into hepatocyte-like cells and these hepatocyte-like cells can significantly express albumin. Furthermore it was also found that MSCs can fuse with the hepatocytes and these cells had the proliferation activity. However, the percentage of transdifferentiation was significantly higher than fusion. So it was considered that MSCs which transdifferentiated into hepatocyte-likes cells played important roles for repairing the injuring liver function. SN - 1687-966X UR - https://doi.org/10.1155/2015/960387 DO - 10.1155/2015/960387 JF - Stem Cells International PB - Hindawi Publishing Corporation KW - ER -