Characterization of Progenitor Cells during Canine Retinal Development
Figure 1
Histological analysis of the retina in embryos ((a)–(d)), fetuses ((e)–(h)) and neonatal ((i)–(l)) dogs. (a) Transversal section of the eye showing the retina (R) and lens (L). (b) In longitudinal section, retina consists of a neuroblastic layer (NBL) formed by an inner marginal (arrow head) and outer nuclear zone (arrows). (c) The retinal pigment epithelium (RPE) is observed to consist of a single layer with oval shaped melanosomes on the apical surface. (d) Electron micrograph showing cells with mitotic activity (*) localized in the NBL. (e) Eye from the fetal stage where retina (R) and lens (L) are evident. (f) Cell migration has formed the inner neuroblastic layer (INBL) and outer neuroblastic layer (ONBL). (g) Some rudimentary photoreceptors were evident at the fetal stage (arrow head). (h) The INBL and ONBL are separated by the transitional space of Chievitz where high resolution exposes a space between the INBL and ONBL without any cells (*). (i) Eye from the postnatal stage where part of the lens (L) and the retina (R) are visible. (j) During the postnatal stage the ganglion cell layer (GCL) was apparent. (k) The RPE was observed as a row of cubic cells. (l) Electron micrograph showing the GCL where the axons (arrow head) are forming the nerve fiber.
