Review Article
Drug Repurposing Is a New Opportunity for Developing Drugs against Neuropsychiatric Disorders
Table 2
Some examples of repurposed drugs for neuropsychiatric disorders.
| Drugs (alphabetic order) | Actions/classes | First intervention | New intervention | References |
| Amantadine | Anticholinergic-like agent | Influenza | Parkinson’s disease, ADHD | [6, 7] | Amphotericin B | NSAID | Antifungal | Bipolar disorder | [120] | Arbaclofen | GABA agonist | Cerebral palsy | Fragile X syndrome | [116, 121–123] | Atomoxetine | NSRI | Parkinson’s diseases | ADHD | [124] | Dexmecamylamine | Nicotinic receptor modulator | Hypertension | Depression | [125, 126] | Galantamine | Acetylcholinesterase inhibitor | Polio, paralysis | Alzheimer’s disease | [127] | Mecamylamine | Nicotinic receptor antagonist | Hypertension | ADHD Depression | [128–131] | Mifepristone | Glucocorticoid receptor type II antagonist | Pregnancy termination | Psychotic major depression, Cushing’s syndrome | [132–135] | Ropinirole | D2 agonist | Hypertension | Parkinson’s disease, idiopathic restless leg syndrome | [136–138] | Tamoxifen | Estrogen receptor | Breast tumor | Bipolar disorder Mania | [139] | Valsartan | Angiotensin receptor blocker | Hypertension | Alzheimer’s disease | [140] |
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NSAID is nonsteroidal anti-inflammatory drug. NSRI is norepinephrine-selective reuptake inhibitor.
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