Retinal Targets ALDH Positive Cancer Stem Cell and Alters the Phenotype of Highly Metastatic Osteosarcoma Cells

Figure 4

Retinal treatment of K7M2 cells changed migration-related cell morphological characteristics and decreased migration capacity. (a) Actin staining with phalloidin revealed that the cell morphology of K7M2 cells was modified with retinal treatment (5 µg/mL for 2 days), showing reduced presence of invadopodia. (b) In vitro invasion assay with 3D-matrigel (2.5%) revealed that K7M2 cells treated with retinal treatment (5 µg/mL for 2 days) migrated slower than nontreated K7M2 control cells.

(a)

(b)