An Overview of Systematic Reviews of Randomized Controlled Trials on Acupuncture Treating Migraine

Table 7

MAs outcomes about adverse events.

Study ID

Outcome

Acute or preventive treatment

Intervention

Control

Follow-up time

RCTs (n)

I2

Model

Scale

Effect

95% CI

value

Linde et al. [14]

Number of patients reporting adverse effects

ND

Acupuncture

②

NR

4 (838)

73%

FEM

OR

0.47

[0.34, 0.65]

<0.00001

Number of patients dropping out due to adverse effects

NR

2 (191)

0%

FEM

OR

0.10

[0.01, 0.78]

0.028

Linde et al. [7]

Number of participants dropping out due to adverse effects

Preventive treatment

Acupuncture

①

NR

7 (931)

0%

FEM

OR

2.84

[0.43, 18.71]

0.28

Number of participants reporting adverse effects

4 (1414)

0%

FEM

OR

1.15

[0.85, 1.56]

0.35

Number of participants with serious adverse events

6 (1071)

0%

FEM

OR

1.29

[0.43, 3.83]

0.65

Number of participants dropping out due to adverse effects

②

NR

4 (451)

0%

REM

OR

0.27

[0.08, 0.86]

0.027

Number of participants reporting adverse effects

5 (931)

78%

REM

OR

0.25

[0.10, 0.62]

0.0027

Number of participants with serious adverse events

3 (721)

0%

REM

OR

1.33

[0.38, 4.73]

0.66

Chen [16]

Number of adverse effects

ND

Acupuncture

ND

NR

5 (567)

0%

FEM

RR

0.11

[0.03, 0.49]

0.003

Pu [24]

Rate of adverse events

Preventive treatment

Acupuncture

②

NR

7 (1126)

77%

REM

RR

0.33

[0.17, 0.64]

0.001

NR: not reported; ND: not defined; ①: sham acupuncture; ②: drug treatment; FEM: fixed effects model; REM: random effects model.