Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

Table 5

Effects of other agents, in a CB receptor-dependent manner, in animal models of CINP.

CINP model		Molecule	Effects	Effects of CB receptor antagonists on the activity of the compound	Reference
Chemotherapy drug	Animal
Paclitaxel	Female and male BALB/c mice	Indomethacin (NSAID) plus minocycline (semisynthetic tetracycline antibiotic)	Reduced established thermal hyperalgesia	CB1 antagonist AM251 antagonised	[53]
Paclitaxel	Male Sprague-Dawley rats	Desipramine (tricyclic antidepressant)	Prevented the development of mechanical and cold allodynia	CB1 antagonist AM251 and CB2 antagonist AM630 partially antagonised	[52]

NSAID, nonsteroidal anti-inflammatory drug.