Pain Research and Management / 2018 / Article / Tab 4

Review Article

Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

Table 4

Effects of cannabidiol in animal models of CINP.

CINP modelEffectsEffects of CB receptor antagonists on the activity of the compoundReference
Chemotherapy drugAnimal

PaclitaxelFemale C57Bl6 micePrevented the development of cold and mechanical allodyniaNo antagonists were used[49]
PaclitaxelFemale C57Bl6 micePrevented the development of mechanical allodyniaCB1 receptor antagonist SR141716 and[50]
CB2 receptor antagonist SR144528 had no effects
5-HT1A receptor antagonist WAY 100635 antagonised
CisplatinMale C57BL/6 miceSuppressed established mechanical allodyniaNo antagonists were used[31]
Did not prevent the development of mechanical allodynia

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