Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

Table 4

Effects of cannabidiol in animal models of CINP.

CINP model		Effects	Effects of CB receptor antagonists on the activity of the compound	Reference
Chemotherapy drug	Animal
Paclitaxel	Female C57Bl6 mice	Prevented the development of cold and mechanical allodynia	No antagonists were used	[49]
Paclitaxel	Female C57Bl6 mice	Prevented the development of mechanical allodynia	CB1 receptor antagonist SR141716 and	[50]
			CB2 receptor antagonist SR144528 had no effects
			5-HT1A receptor antagonist WAY 100635 antagonised
Cisplatin	Male C57BL/6 mice	Suppressed established mechanical allodynia	No antagonists were used	[31]
		Did not prevent the development of mechanical allodynia