Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

Table 3

Effects of CB receptor agonists in animal models of CINP.

CINP model		CB receptor agonist	Effects	Effects of CB receptor antagonists on the activity of the compound	Reference
Chemotherapy drug	Animal
Nonselective CB1/CB2 receptor agonists
Cisplatin	Male C3H/HeN mice	2-AG	Suppressed established mechanical hyperalgesia	CB1 receptor antagonist AM281 antagonised	[26]
				CB2 receptor antagonist AM630 had no effect
Cisplatin	Male C3H/HeN mice	AEA	Suppressed established mechanical hyperalgesia	CB1 antagonist AM281 antagonised	[25]
				CB2 antagonist AM630 had no effects
Paclitaxel	CD1 and C57BL/6J mice	THC	Suppressed established mechanical and cold allodynia	No antagonists were used	[30]
Cisplatin	Male C57BL/6 mice	THC	Suppressed established mechanical allodynia	No antagonists were used	[31]
			Did not prevent the development of mechanical allodynia
Paclitaxel	CD1 and C57BL/6J mice	CP55,940	Suppressed established mechanical and cold allodynia	CB2 antagonist AM630 antagonised	[32]
Paclitaxel	Male Wistar rats	WIN	Suppressed established thermal hyperalgesia and mechanical allodynia	CB1 antagonist SR141716A antagonised	[33]
Vincristine	Male SD rats	WIN	Suppressed established mechanical allodynia	Both CB1 antagonist SR141716 and CB2 antagonist SR144528 antagonised	[34]
Cisplatin	Male Wistar rats	WIN	Prevented the development of mechanical allodynia	No antagonists were used	[35]
Paclitaxel	Male Wistar rats	WIN	Prevented the development of thermal hyperalgesia and mechanical allodynia	No antagonists were used	[36]
Cisplatin	Male Wistar rats	WIN	Prevented the development of mechanical allodynia	No antagonists were used	[37]
Cisplatin	Male Wistar rats	WIN	Suppressed established mechanical allodynia	Both CB1 antagonist AM251 and CB2 antagonist SR144528 antagonised	[38]
Paclitaxel	Male SD rats	WIN	Prevented the development of mechanical and cold allodynia	CB1 receptor antagonist AM251 antagonised mechanical allodynia but not cold allodynia	[39]
				CB2 receptor antagonist AM630 did not reliably antagonise both mechanical and cold allodynia
CB1 receptor-selective agonists
Cisplatin	Male Wistar rats	ACEA	Suppressed established mechanical allodynia	CB1 antagonist AM251 antagonised	[38]
Paclitaxel	Male CD1 and C57BL/6J mice	GAT211 (CB1 PAM)	Suppressed mechanical and cold allodynia	CB1 receptor antagonist AM251 antagonised	[29]
				CB2 receptor antagonist AM630 had no effect
CB2 receptor-selective agonists
Vincristine	Male SD rats	AM1241	Suppressed established mechanical allodynia	CB1 antagonist SR141716 had no effect	[34]
				CB2 antagonist SR144528 antagonised
Paclitaxel	Male SD rats	AM1241 and AM1714	Suppressed established mechanical allodynia	CB1 antagonist SR141716 had no effect	[40]
				CB2 antagonist SR144528 antagonised
Cisplatin and paclitaxel	Male SD rats	AM1710	Suppressed established mechanical and cold allodynia	CB1 antagonist AM251 had no effect	[41]
				CB2 antagonist AM630 antagonised
Paclitaxel	Male SD rats	AM1710	Prevented the development of mechanical and cold allodynia	CB1 receptor antagonist AM251 had no effect	[39]
				CB2 receptor antagonist AM630 antagonised
Paclitaxel	CD1 and C57BL/6J mice	AM1710	Suppressed established mechanical and cold allodynia	CB2 antagonist AM630 antagonised	[30]
Paclitaxel	Male SD rats	MDA7	Suppressed established mechanical allodynia	No antagonists were used	[42]
Paclitaxel	Male SD rats and mice (strain not specified)	MDA7	Suppressed established mechanical allodynia	CB2 antagonist AM630 antagonised	[43]
Paclitaxel	Male SD rats	MDA7	Prevented the development of mechanical allodynia	No antagonists were used in paclitaxel-induced mechanical allodynia	[44]
Paclitaxel	Male SD rats and mice (strain not specified)	MDA19	Suppressed established mechanical allodynia	No antagonists were used	[45]
Paclitaxel	Male C57BL/6J mice	LY2828360	Suppressed established mechanical and cold allodynia	No antagonists were used	[46]
Cisplatin	Male Wistar rats	JWH133	Suppressed established mechanical allodynia	CB2 antagonist SR144528 antagonised	[38]
Paclitaxel	Male Swiss mice	BCP	Prevented the development of mechanical allodynia	CB1 receptor antagonist AM251 had no effect	[47]
			Suppressed established mechanical allodynia	CB2 receptor antagonist AM630 antagonised

AEA, N-arachidonoylethanolamine (anandamide); BCP, β-caryophyllene; PAM, positive allosteric modulator; SD, Sprague-Dawley; THC, Δ⁹-tetrahydrocannabinol; WIN, WIN 55,212-2.