Pain Research and Management / 2018 / Article / Tab 3

Review Article

Targeting the Endocannabinoid System for Prevention or Treatment of Chemotherapy-Induced Neuropathic Pain: Studies in Animal Models

Table 3

Effects of CB receptor agonists in animal models of CINP.

CINP modelCB receptor agonistEffectsEffects of CB receptor antagonists on the activity of the compoundReference
Chemotherapy drugAnimal

Nonselective CB1/CB2 receptor agonists
CisplatinMale C3H/HeN mice2-AGSuppressed established mechanical hyperalgesiaCB1 receptor antagonist AM281 antagonised[26]
CB2 receptor antagonist AM630 had no effect
CisplatinMale C3H/HeN miceAEASuppressed established mechanical hyperalgesiaCB1 antagonist AM281 antagonised[25]
CB2 antagonist AM630 had no effects
PaclitaxelCD1 and C57BL/6J miceTHCSuppressed established mechanical and cold allodyniaNo antagonists were used[30]
CisplatinMale C57BL/6 miceTHCSuppressed established mechanical allodyniaNo antagonists were used[31]
Did not prevent the development of mechanical allodynia
PaclitaxelCD1 and C57BL/6J miceCP55,940Suppressed established mechanical and cold allodyniaCB2 antagonist AM630 antagonised[32]
PaclitaxelMale Wistar ratsWINSuppressed established thermal hyperalgesia and mechanical allodyniaCB1 antagonist SR141716A antagonised[33]
VincristineMale SD ratsWINSuppressed established mechanical allodyniaBoth CB1 antagonist SR141716 and CB2 antagonist SR144528 antagonised[34]
CisplatinMale Wistar ratsWINPrevented the development of mechanical allodyniaNo antagonists were used[35]
PaclitaxelMale Wistar ratsWINPrevented the development of thermal hyperalgesia and mechanical allodyniaNo antagonists were used[36]
CisplatinMale Wistar ratsWINPrevented the development of mechanical allodyniaNo antagonists were used[37]
CisplatinMale Wistar ratsWINSuppressed established mechanical allodyniaBoth CB1 antagonist AM251 and CB2 antagonist SR144528 antagonised[38]
PaclitaxelMale SD ratsWINPrevented the development of mechanical and cold allodyniaCB1 receptor antagonist AM251 antagonised mechanical allodynia but not cold allodynia[39]
CB2 receptor antagonist AM630 did not reliably antagonise both mechanical and cold allodynia
CB1 receptor-selective agonists
CisplatinMale Wistar ratsACEASuppressed established mechanical allodyniaCB1 antagonist AM251 antagonised[38]
PaclitaxelMale CD1 and C57BL/6J miceGAT211 (CB1 PAM)Suppressed mechanical and cold allodyniaCB1 receptor antagonist AM251 antagonised[29]
CB2 receptor antagonist AM630 had no effect
CB2 receptor-selective agonists
VincristineMale SD ratsAM1241Suppressed established mechanical allodyniaCB1 antagonist SR141716 had no effect[34]
CB2 antagonist SR144528 antagonised
PaclitaxelMale SD ratsAM1241 and AM1714Suppressed established mechanical allodyniaCB1 antagonist SR141716 had no effect[40]
CB2 antagonist SR144528 antagonised
Cisplatin and paclitaxelMale SD ratsAM1710Suppressed established mechanical and cold allodyniaCB1 antagonist AM251 had no effect[41]
CB2 antagonist AM630 antagonised
PaclitaxelMale SD ratsAM1710Prevented the development of mechanical and cold allodyniaCB1 receptor antagonist AM251 had no effect[39]
CB2 receptor antagonist AM630 antagonised
PaclitaxelCD1 and C57BL/6J miceAM1710Suppressed established mechanical and cold allodyniaCB2 antagonist AM630 antagonised[30]
PaclitaxelMale SD ratsMDA7Suppressed established mechanical allodyniaNo antagonists were used[42]
PaclitaxelMale SD rats and mice (strain not specified)MDA7Suppressed established mechanical allodyniaCB2 antagonist AM630 antagonised[43]
PaclitaxelMale SD ratsMDA7Prevented the development of mechanical allodyniaNo antagonists were used in paclitaxel-induced mechanical allodynia[44]
PaclitaxelMale SD rats and mice (strain not specified)MDA19Suppressed established mechanical allodyniaNo antagonists were used[45]
PaclitaxelMale C57BL/6J miceLY2828360Suppressed established mechanical and cold allodyniaNo antagonists were used[46]
CisplatinMale Wistar ratsJWH133Suppressed established mechanical allodyniaCB2 antagonist SR144528 antagonised[38]
PaclitaxelMale Swiss miceBCPPrevented the development of mechanical allodyniaCB1 receptor antagonist AM251 had no effect[47]
Suppressed established mechanical allodyniaCB2 receptor antagonist AM630 antagonised

AEA, N-arachidonoylethanolamine (anandamide); BCP, β-caryophyllene; PAM, positive allosteric modulator; SD, Sprague-Dawley; THC, Δ9-tetrahydrocannabinol; WIN, WIN 55,212-2.

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