Review Article

Serrated Polyposis: An Enigmatic Model of Colorectal Cancer Predisposition

Table 2

Prevalence of genetic and epigenetic alteration in the different subtypes of serrated polyps by combining all comparable data from [73, 7584].

Polyp typeBRAF mutationKRAS mutationCIMP-H*MLH1 methylationMGMT methylation

HP
 Microvesicular66.3%12.3%47.4% 39.5% 26.3%
 Goblet-cell20%48.4%14.3% 14.3%0%
 All subtypes51.5%22.1%38.5%27%14.8%
SSA/P83.9%5.8%75.9%42.6%25%
TSA62.5%22.4%79.3%47.5%74.2%

*CIMP-H: high level of CIMP in polyps defined by ≥2/5 methylated markers from O’Brien et al. [76, 85].