Review Article

Serrated Polyposis: An Enigmatic Model of Colorectal Cancer Predisposition

Figure 3

The canonical serrated pathway showing progression through MVHP (microvessicular hyperplastic polyp) to SSA/P (sessile serrated adenoma/sessile serrated polyp) and SSA/P-D (SSA/P with dysplasia) to CRC with CIMP and high levels of BRAF mutation frequently arising in the proximal colon. CRC with CIMP can evolve into MSI-H and non-MSI-H subtypes. Though KRAS mutation can be observed in CIMP CRC, these are relatively rare [103, 104].
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