PPARs and the Development of Type 1 Diabetes

Table 1

Overview of treatments that promote PPAR expression and prevent autoimmune diabetes in NOD mice.

Drug	Delivery	Diabetes incidence	Reference
Fenofibrate	Diet from age 3 weeks	0%	[44]
Troglitazone	Oral gavage from age 3 weeks	22%	[149]
Rosiglitazone	Oral gavage from age 3 weeks	22%	[149]
Epigallocatechin	Water from age 5 weeks	25%	[151]
Curcumin	i.p. every other day	33 % (CYP-induced diabetes)	[153]
Cannabidiol	i.p. age 6-12 weeks	30%	[155]
Capsaicin	Oral gavage at age 9 or 10 weeks	20%	[158]
Taurine	Water to pregnant mothers	40% (after 24 weeks)	[160]
Omega-3	Diet from age 5 weeks	33%	[157]
Gluten-free diet	Diet from breeding	15%	[163]