Peroxisome Proliferator-Activated Receptor γ Regulates the Expression of Lipid Phosphate Phosphohydrolase 1 in Human Vascular Endothelial Cells

Figure 5

PPARγ increases the promoter activity of LPP1 via binding to PPRE. (a) The pGL3/LPP1-luc and pGL3/mLPP1-luc plasmids with the 1.7 kb of 5′-flanking region of the human LPP1 gene with 3 putative PPREs and the mutations depicted. (b) BAECs were transfected with pGL3/LPP1-luc or pGL3/mLPP1-luc plasmids together with β-gal plasmids. Data were fold induction of luciferase activity and expressed as mean ± SEM of four independent experiments. *𝑃<0.05; **𝑃<0.01 versus control.

(a)

(b)