Peroxisome Proliferator-Activated Receptor γ Regulates the Expression of Lipid Phosphate Phosphohydrolase 1 in Human Vascular Endothelial Cells

Figure 2

PPARγ increases LPP1 expression in mRNA levels. Confluence HUVECs were coinfected with adenoviruses expressing different isoforms of human PPARs together with Ad-tTA. Cells were maintained in the presence or absence of tetracycline for 24 h and then treated with the selective agonists (fenofibrate, GW501516, or rosiglitazone) or vehicle (DMSO). LPP1 mRNA levels were normalized to GAPDH and expressed as mean ± SEM of three independent experiments. *𝑃<0.05; **𝑃<0.01 versus control.