Radix Astragali Improves Dysregulated Triglyceride Metabolism and Attenuates Macrophage Infiltration in Adipose Tissue in High-Fat Diet-Induced Obese Male Rats through Activating mTORC1-PPARγ Signaling Pathway
Figure 1
RA treatment has no effect on body weight and intra-abdominal white adipose tissue mass but decreases adipocyte size. (a) Body weights of rats fed standard chow without RA administration (NFD-C) and with RA administration (NFD-RA), high-fat diet without RA administration (HFD-C) and high-fat diet with RA administration (HFD-RA) (20 weeks, here and throughout, except as noted, –8/group) (b) epididymal (epi), perirenal (peri), and epi + peri fat pad weights (normalized to body weights here) in rats in the NFD-C, NFD-RA, HFD-C, and HFD-RA groups (20 weeks, –8/group). (c) Histology of epididymal adipose tissue from rats in the NFD-C, NFD-RA, HFD-C, and HFD-RA groups. Scale bar: 50 μm. (d) Mean adipocyte size in rats in the NFD-C, NFD-RA, HFD-C, and HFD-RA groups (/group). * (HFD-C group versus NFD-C group) and # (HFD-RA group versus HFD-C group).
