Peroxisome Proliferator-Activated Receptor Gamma Exacerbates Concanavalin A-Induced Liver Injury via Suppressing the Translocation of NF-κB into the Nucleus
Figure 3
Histopathological examination of liver sections stained with H-E at 20 h after Con A injection revealed more extensive liver necrosis in the pioglitazone-treated mice (c) in comparison with that in the nonpioglitazone-treated mice (a). TUNEL assay at 20 h after Con A injection revealed more extensive liver apoptosis in the pioglitazone-treated mice (d) as compared with that in the nonpioglitazone-treated mice (b). The number of TUNEL-positive cells/100 cells was three-times higher in the livers of the pioglitazone-treated mice as compared with that in the livers of the nonpioglitazone-treated mice ( versus , ).
