Research Article

Peroxisome Proliferator-Activated Receptor Agonists Differentially Regulate Inhibitor of DNA Binding Expression in Rodents and Human Cells

Figure 1

Fenofibrate downregulates Id2 gene expression in rats. Left panel: relative amount of mRNA of liver Id2, after 4-day treatment with or without fenofibrate in virgin and pregnant rats, measured by semiquantitative RT-PCR. Values were normalized against glyceraldehyde-3-phosphate dehydrogenase (GAPDH) expression and were represented using arbitrary units. Capital letters correspond to the statistical comparisons between pregnant and virgin rats receiving the same treatment. Small letters correspond to the statistical comparisons between rats receiving different drug doses. Values not sharing a common letter are significantly different at . Each value represents the mean ± standard error of five animals. Right panel: starvation downregulates Id2 gene expression. Relative amount of mRNA of liver Id2 from pregnant rats fed with standard pellet or fasted 24 h, measured by semiquantitative RT-PCR. Values were normalized against GAPDH expression and were represented using arbitrary units. Asterisk represents significantly different at .
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