Modulation of Preactivation of PPAR-β on Memory and Learning Dysfunction and Inflammatory Response in the Hippocampus in Rats Exposed to Global Cerebral Ischemia/Reperfusion

Table 2

Effect of GW0742 on the level of inflammatory factors in hippocampus of global cerebral ischemia/reperfusion rats.

Group	TNF-𝛼 (ng/mL)	IL-1𝛽 (pg/mL)	IL-6 (ng/mL)	IL-10 (ng/mL)
Sham group	2.24±0.51	209.14±48.29	5.90±0.78	3.11±0.26
Model group	6.51±1.05^∗∗	545.14±59.81^∗∗	13.39±1.74^∗∗	1.97±0.18^∗∗
GW0742-20 group	5.71±0.98	495.09±65.18	11.82±1.33	2.09±0.12
GW0742-60 group	5.08±0.64^#	452.20±45.56^#	9.87±0.91^##	2.28±0.17^#
GW0742-180 group	4.11±0.58^##/▵	369.99±60.08^##/▵	8.41±1.06^##/▵	2.72±0.19^##/▵

Dates are expressed as mean ± SD (𝑛=5). **𝑃<0.01 compared with sham operation group; ^#𝑃<0.05, ^##𝑃<0.01 compared with model group; ^▵𝑃<0.05 compared with GW0742 20 group.