Review Article

Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition

Table 2

Summary of PPAR expression patterns.

(a) Global expression pattern
GeneSpeciesExpression localizationReferences

PPARαRodentsCardiomyocytes[6, 8]
Hepatocytes
HumanHeart[6, 8]
Kidney
Large intestine
Leydig and seminiferous tubule cells[12]
Liver[6, 8]
Skeletal muscle
Uterus[12]
Ovary (Theca and stroma cells)

PPARβRodentsUbiquitous[6, 8]
HumanUbiquitous[6, 8]

PPARγRodentsBrown and white adipose tissue[6, 8]
Lymphoid organs
Retina
Skeletal muscle
Uterus[12]
Granulosa cells, corpus luteum
HumanColon[6, 8]
Kidney
Liver
Skeltal muscle
Vascular endothelium
White adipose tissue
Sertoli cells[12]
Uterus
Granulosa cells

(B) Placental expression pattern

PPARα, β, γRodentsTerm placenta[4, 9]
HumanVillous trophoblastic cells and syncytiotrophoblasts[4, 9, 10]
Amnion, chorion, and amnion derived-WISH cell line