Placental Implications of Peroxisome Proliferator-Activated Receptors in Gestation and Parturition
Figure 1
(a) Schematic representation of PPARγ genes, mRNA, and proteins. The exons A1, A2, B can be alternatively spliced to give rise to the different PPARγ isoforms. The boxes 1 to 6 correspond to exons which are common to PPARγ1, γ2, γ3 genes. ATG is the initiation transcription site. The molecular weight of these isoforms ranges from 49 to 56 kDa. (b) Schematic representation of typical nuclear receptor structure. AF1: activating function 1 (ligand-independent function), AF2: activating function 2 (ligand-dependent function), NLS: nuclear signal localization.
